A postdoctoral position is available in the Computational Neuroscience Unit of Dr. Erik De Schutter at the Okinawa Institute of Science and Technology, Japan (http://www.irp.oist.jp/cns/) to model molecular aspects of cerebellar Purkinje cell function.
We study the signaling pathways involved in cerebellar long-term depression at the parallel fiber to Purkinje cell synapse. You will be able to use a detailed stochastic model using the STEPS simulator (http://steps.sourceforge.net/) that replicates calcium uncaging experiments in detail (Antunes and De Schutter 2012). This well mixed model with about 400 different reactions has generated new insights in the sources of stochasticity in synaptic plasticity induction. Now we want to expand this work in two directions: to include diffusion, distributing reactions between the spine and dendrite, and to include induction of parallel fiber long-term potentiation. Candidates should have experience with modeling molecular reactions. Knowledge of signaling pathways involved in synaptic plasticity preferred.
Good English language skills are essential. There will be ample opportunity to interact with modelers and software developers in the lab who are working on several Purkinje cell and cerebellar related projects and with other scientists at the English language multi-disciplinary environment of OIST.
Write me if interested. Include CV and names of two references.
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